By car:

Follow directions to 'Zentrum', 'Stadtmitte' and/or 'Hauptbahnhof', which is Munich's Central Train Station.
Opposite to the main entrance of the railway station is the department store 'KARSTADT' and a few meters on the right hand side the 'Bayerstrasse'.
Take your right from Hauptbahnhof and Bayerstrasse into Schillerstrasse. On the corner there is a 'C&A' store. The Hotel is located on the right hand side, on the beginning of Schillerstrasse.

Parking:

1) Your car can be parked safely in the 'Stachus Parkgarage' located next street ('Adolf Kolping Str.') to the left, a few meters from the Hotel. Please note opening times: Monday-Wednesday from 7 AM to Midnight, Thursday-Saturday from 7 to 2 AM, Sundays and bank holidays from 10 to Midnight.
As a hotel guest you receive a reduction when stamping your parking ticket (Parking fee is 15 EUR/24 hours).

2) Parking garage of German Railways: drive down 'Schillerstrasse' and turn next street right ('Schwanthalerstrasse') and then next street turn right again ('Senefelder Strase'). The garage is located on the left hand side. It is open 24 hours per day, 7 days a week (Parking fee is EUR 10,- as a hotel guest).
Link: http://www.dbbahnpark.info/Hoteltarif-M10.pdf

Using public transport system:

Using trains, buses or trams take exit HAUPTBAHNHOF (Munich's Central Train Station)
Take exit 'Bahnhofsplatz' or 'Bayerstrasse'. On the corner of Bayerstrasse and Schillerstrasse there is a C&A store. The Hotel is located on the right hand side of Schillerstrasse, on the beginning of the street.

From the airport:

you take S Bahn (suburban trains) line 8 or 1 or the Lufthansa Airport Bus to HAUPTBAHNHOF. Travelling time is around 45 minutes.